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Dose adjustment in patients with slight or moderate impaired liver (5-9 points on a scale child-Pugh) is not required, however, when poor tolerability of the drug dose reduced to 20 mg 2 times a day. In patients with severe violations of the liver (more 9 points on a scale child-Pugh) the use of the drug has not been investigated (see section "Contraindications").

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On the part of hearing and vestibular apparatus: dizziness, tinnitus, deafness *.