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Dose adjustment in patients with slight or moderate impaired liver (5-9 points on a scale child-Pugh) is not required, however, when poor tolerability of the drug dose reduced to 20 mg 2 times a day. In patients with severe violations of the liver (more 9 points on a scale child-Pugh) the use of the drug has not been investigated (see section "Contraindications").
Violations of kidney function. If (Cl — creatinine 50-80 ml/min) and moderate (Cl — creatinine 30-49 ml/min) renal insufficiency the pharmacokinetics of generic Penegra for btc after a single oral dose of 50 mg not changed. In severe renal failure (Cl creatinine ≤30 ml/min) clearance of buy Penegra online btc or credit card is reduced, leading to approximately twofold increase in AUC values (100%) and Cmax (88%) compared with those with normal indices of renal function in patients in the same age group.
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