Inside, approximately 1 hour before planned sexual activity. Single dose for adults is 50 mg 1 time a day. Taking into account efficiency and portability the dose can be increased to 100 mg. Maximum daily dose of 100 mg.

Effects on ability to drive vehicles and mechanisms

A condition in which no sexual activity is recommended (e.g. severe cardiovascular disorders such as unstable angina or heart failure, severe).

After taking the drug inside pay for Tadalafil with bitcoin is rapidly absorbed. The absolute bioavailability averages 40 % (25-63 %). In vitro how to buy Tadalafil with bitcoin online pharmacy at a concentration of about 1.7 ng/ml (3.5 nm) inhibits PDE5 man at 50 %. After a single dose of buy Tadagra Softgel online btc or credit card at a dose of 100 mg orally average maximum concentration (Cmax) of free generic Tadalafil for btc in the blood plasma is 18 ng/ml (38 nm) and achieved in the fasting average for 60 min (30-120 min). When taken in combination with fatty food the rate of absorption is reduced: Cmax is reduced by an average of 29% and the time to maximum concentration (Tmax) is increased by 60 min, however, the extent of absorption was not significantly changed (area under the curve "concentration-time" (AUC) is reduced by 11 %).

In a randomized double-blind placebo-controlled study studied the effect of a change in the dose of buy Tadagra Softgel online bitcoin or credit card (100 mg) in men (n=568) with erectile dysfunction and arterial hypertension taking more than two antihypertensive drugs. buy Tadalafil online btc or credit card have improved erections in 71% of men compared to 18% in the placebo group. The frequency of adverse effects was comparable to that in other patient groups, as well as for persons taking more than three antihypertensive drugs.

In vitro studies showed that generic Tadagra Softgel for bitcoin selective towards PDE-5 that is involved in the development process of erection. Its activity against PDE5 superior activity against other known phosphodiesterase. buy Tadalafil online btc or credit card is 10 times less selective towards PDE-6, which participates in photoperiodic in the retina. At maximum recommended doses of buy Tadalafil btc to 80 times less selective towards PDE-1 and 700 times or more in respect of PDE-2, 3, 4, 7, 8, 9, 10 and 11. Activity cheap Tadalafil accept bitcoin for PDE5 is approximately 4000 times greater than its activity against PDE-3 (zikloadenosinmonofosfat (camp) - specific phosphodiesterase), participating in the regulation of myocardial contractility.

Drugs intended for the treatment of erectile dysfunction, should not appoint men for whom sexual activity is undesirable.

Treatment of erectile dysfunction characterized by the inability to achieve or sustain a penile erection sufficient for satisfactory sexual intercourse.

Patients with mild (creatinine clearance (CC) 50 - 80 ml/min) and moderate (CC 30 to 49 ml/min) renal insufficiency the pharmacokinetics of cheap Tadalafil accept bitcoin after a single oral dose of 50 mg not changed. In patients with severe renal insufficiency (KK less 30 ml/min), and the elderly clearance of buy Tadalafil bitcoin lower and AUC increased by 100% and Cmax by 88 % in comparison to patients with normal renal function in the same age group.