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The drug is not intended for use in women (see "Contraindications").

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Realization of physiological mechanism of erection is associated with release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to increased levels of cGMP, the subsequent relaxation of smooth muscle of the cavernous body and increase blood flow.

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Marked hepatic impairment, hypotension (blood pressure < 90/50 mm Hg.St.), recently moved stroke or myocardial infarction and known hereditary degenerative retinal disorders such as retinitis pigmentosa.

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