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buy Cialis with bitcoin or credit card is a potent and selective inhibitor of cGMP-specific phosphodiesterase 5 (PDE-5) within the corpora cavernosa, where PDE5 is responsible for the breakdown of cGMP. The effects of buy Tadalafil with btc or credit card on erection are peripheral character. purchase Cialis for bitcoin online pharmacy do not have a direct relaxing action on isolated cavernous body of man, but powerfully enhances relaxing effect of NO on this tissue. When you activate a metabolic pathway NO / cGMP, what happens when sexual stimulation, inhibition of PDE5 sildenafilom leads to increased levels of cGMP in the cavernous bodies. Thus, to buy Cialis bitcoin caused the required pharmacological effect, if you are sexually aroused.
Dose adjustment in patients with slight or moderate impaired liver (5-9 points on a scale child-Pugh) is not required, however, when poor tolerability of the drug dose reduced to 20 mg 2 times a day. In patients with severe violations of the liver (more 9 points on a scale child-Pugh) the use of the drug has not been investigated (see section "Contraindications").
Violations of kidney function. If (Cl — creatinine 50-80 ml/min) and moderate (Cl — creatinine 30-49 ml/min) renal insufficiency the pharmacokinetics of discount Cialis with bitcoin after a single oral dose of 50 mg not changed. In severe renal failure (Cl creatinine ≤30 ml/min) clearance of generic Cialis for btc is reduced, leading to approximately twofold increase in AUC values (100%) and Cmax (88%) compared with those with normal indices of renal function in patients in the same age group.
In patients with mild and moderate liver cirrhosis (class A and b on a scale child-Pugh) clearance sale super Cialis (Tadalafil) accept btc is reduced, leading to increase in AUC (84%) and Cmax (47%) compared with those with normal indices of liver function in patients of the same age group. Pharmacokinetic parameters of how to buy Cialis with btc online pharmacy in patients with severe hepatic impairment has not been studied.
The efficacy and safety of purchase Cialis (Tadalafil) for btc online pharmacy was evaluated in 21 randomized, double blind, placebo-controlled study lasting up to 6 months in 3000 patients aged 19 to 87 years with erectile dysfunction of various etiologies (organic, psychogenic, or mixed). Efficacy of the drug was assessed globally using diary erections, international index of erectile function (validierung questionnaire on the state of sexual function) and polling partner.
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The physiological mechanism that leads to erection, including the release of nitric oxide (NO) in cavernous bodies during sexual arousal. The released nitric oxide activates the enzyme guanylate cyclase, which stimulates raising the level of cyclic guanosine monophosphate (cGMP) which in turn causes relaxation of the smooth muscles of the corpora cavernosa, thereby blood flow.
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